Article
Differential localization patterns of myristoylated and nonmyristoylated c-Src proteins in interphase and mitotic c-Src overexpresser cells.
Journal of cell science - 1 Jul 1993
David-Pfeuty T, Bagrodia S, Shalloway D
Abstract excerpt
Myristoylation of pp60src is required for its membrane attachment and transforming activity. The mouse monoclonal antibody, mAb327, which recognizes both normal, myristoylated pp60c-src and a nonmyristoylated mutant, pp60c-src/myr-, has been used to compare the effects of preventing myristoylatio...
Topics
- 3T3 Cells
- Animals
- Antibodies, Monoclonal
- Biological Transport, Active
- Cell Nucleus
- Cytoplasm
- Fluorescent Antibody Technique
- Gene Expression
- Interphase
- Mice
- Mitosis
- Mutation
- Myristic Acids
- Proto-Oncogene Proteins pp60(c-src)