Article
pp60c-src binding to polyomavirus middle T-antigen (MT) requires residues 185 to 210 of the MT sequence.
Journal of virology - 1 Jul 1997
Brewster C E, Glover H R, Dilworth S M
Abstract excerpt
Interaction with the src family of tyrosine kinases is crucial to the transforming action of polyomavirus middle T-antigen (MT). Association with MT activates the tyrosine kinase activity of pp60(c-src) and, through subsequent MT phosphorylation, creates binding sites for signalling molecules who...
Topics
- Amino Acid Sequence
- Animals
- Antigens, Polyomavirus Transforming
- Cell Line
- Molecular Sequence Data
- Mutation
- Phenotype
- Phosphatidylinositol 3-Kinases
- Phosphotransferases (Alcohol Group Acceptor)
- Proto-Oncogene Proteins pp60(c-src)
- Rats
- Structure-Activity Relationship
- Transformation, Genetic