Article
Myristylation of pp60c-src is not required for complex formation with polyomavirus middle-T antigen.
Journal of virology - 1 Oct 1990
Wyss A, Kaech S, Ballmer-Hofer K
Abstract excerpt
Middle-T antigen (middle-T), the transforming gene product of polyomavirus, associates with several cellular tyrosine kinases, such as pp60c-src. Complex formation leads to kinase activation and is essential for cell transformation. Middle-T-associated as well as uncomplexed pp60c-src is predominantly found in the plasma membrane. We transfected mouse 3T3 fibroblasts with a mutated c-src gene (2Ac-src), allowing...
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