Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

c-Src but not Fyn promotes proper spindle orientation in early prometaphase.

The Journal of biological chemistry - 20 Jul 2012

Nakayama Yuji, Matsui Yuki, Takeda Yumi, Okamoto Mai, Abe Kohei, Fukumoto Yasunori, Yamaguchi Naoto

Abstract excerpt

Src family tyrosine kinases (SFKs) participate in mitotic signal transduction events, including mitotic entry, cleavage furrow ingression, and cytokinesis abscission. Although SFKs have been shown to associate with the mitotic spindle, the role of SFKs in mitotic spindle formation remains unclear. Here, we show that c-Src promotes proper spindle orientation in early prometaphase. Src localizes close to spindle...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aurora Kinase B
Share to Aurora Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CSK Tyrosine-Protein Kinase

Share to HeLa Cells

Share to Protein-Tyrosine Kinases

Share to Proto-Oncogene Proteins c-fyn

Share to Spindle Apparatus

Share to src-Family Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 22689581
DOI: 10.1074/jbc.M112.341578
PMCID: PMC3408174

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

c-Src but not Fyn promotes proper spindle orientation in early prometaphase.PMID 22689581Read ↗

The Spindle Orientation Machinery Beyond Mitosis: When Cell Specialization Demands Polarization.Semantic proximity Read ↗

The spindle pole bodies facilitate nuclear envelope division during closed mitosis in fission yeast.Semantic proximity Read ↗

Mitotic spindle (DIS)orientation and DISease: Cause or consequence?Semantic proximity Read ↗

Fyn kinase is involved in cleavage furrow ingression during meiosis and mitosisSemantic proximity Read ↗

Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity.Semantic proximity Read ↗

Cytokinesis Failure Leading to Chromosome Instability in v-Src-Induced Oncogenesis.Semantic proximity Read ↗

Ste20/GCK kinase Nak1/Orb3 polarizes the actin cytoskeleton in fission yeast during the cell cycle.Semantic proximity Read ↗

A MAP kinase-dependent actin checkpoint ensures proper spindle orientation in fission yeast.Semantic proximity Read ↗

Kinesin 6 family member Subito participates in mitotic spindle assembly and interacts with mitotic regulators.Semantic proximity Read ↗

Knockdown of B-Raf impairs spindle formation and the mitotic checkpoint in human somatic cells.Semantic proximity Read ↗

Role of astral microtubules and actin in spindle orientation and migration in the budding yeast, Saccharomyces cerevisiae.Semantic proximity Read ↗

Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.