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Article

Activation of human pp60c-src.

Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Jan 1996

Bjorge J D, O'Connor T J, Fujita D J

Abstract excerpt

pp60c-src and the structurally related members of the Src family are non-receptor tyrosine kinases that reside within the cell associated with cell membranes and appear to transduce signals from transmembrane receptors to the cell interior. Many intracellular pathways can be stimulated upon Src a...

Topics

CSK Tyrosine-Protein Kinase
Cells, Cultured
Enzyme Activation
Humans
Melanocytes
Melanoma
Mutation
Phosphorylation
Protein-Tyrosine Kinases
Proto-Oncogene Proteins pp60(c-src)
Signal Transduction
Tumor Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

src-Family Kinases

Source

Identifiers

PMID: 8960354
DOI: 10.1139/o96-052

Genes

CSK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8960354-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Activation of human pp60c-src.PMID 8960354Read ↗

<i>SRC</i> gene expression in human cancer: the role of transcriptional activationSemantic proximity Read ↗

Identification of sites on epidermal growth factor receptors which are phosphorylated by pp60src in vitro.Semantic proximity Read ↗

Mutational activation of pp60(c-src) leads to a tumorigenic phenotype in a preneoplastic Syrian hamster embryo cell line.Semantic proximity Read ↗

Enhanced EGF mitogenic response is associated with enhanced tyrosine phosphorylation of specific cellular proteins in fibroblasts overexpressing c-src.Semantic proximity Read ↗

Autophosphorylation of purified c-Src at its primary negative regulation site.Semantic proximity Read ↗

Functional dissection of transformation by c‐Src and v‐SrcSemantic proximity Read ↗

Association of type I phosphatidylinositol kinase activity with mutationally activated forms of human pp60c-src.Semantic proximity Read ↗

The role of Src in solid and hematologic malignancies: development of new-generation Src inhibitors.Semantic proximity Read ↗

Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src.Semantic proximity Read ↗

Characterization of pp60c-src tyrosine kinase activities using a continuous assay: autoactivation of the enzyme is an intermolecular autophosphorylation process.Semantic proximity Read ↗

Analysis of mutant forms of the c-src gene product containing a phenylalanine substitution for tyrosine 416.Semantic proximity Read ↗

Regulation of the oncogenic activity of the cellular src protein requires the correct spacing between the kinase domain and the C-terminal phosphorylated tyrosine (Tyr-527).Semantic proximity Read ↗

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