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Article

Myristylation is required for Tyr-527 dephosphorylation and activation of pp60c-src in mitosis.

Molecular and cellular biology - 1 Mar 1993

Bagrodia S, Taylor S J, Shalloway D

Abstract excerpt

The chicken proto-oncoprotein c-Src is phosphorylated by p34cdc2 during mitosis concomitant with increased c-Src tyrosine kinase activity. On the basis of indirect evidence, we previously suggested that this is caused by partial dephosphorylation at Tyr-527, the phosphorylation of which suppresses c-Src kinase activity. In support of this hypothesis, we now show that treatment of cells with a protein tyrosine...

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Identifiers

PMID: 7680096
DOI: 10.1128/mcb.13.3.1464-1470.1993
PMCID: PMC359457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Myristylation is required for Tyr-527 dephosphorylation and activation of pp60c-src in mitosis.PMID 7680096Read ↗

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Altered tyrosine 527 phosphorylation and mitotic activation of p60c-src.Semantic proximity Read ↗

Association of p60c-src with polyoma virus middle-T antigen abrogating mitosis-specific activation.Semantic proximity Read ↗

Aberrant protein phosphorylation at tyrosine is responsible for the growth-inhibitory action of pp60v-src expressed in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation.Semantic proximity Read ↗

CDC37 is required for p60v-src activity in yeast.Semantic proximity Read ↗

Autophosphorylation of purified c-Src at its primary negative regulation site.Semantic proximity Read ↗

Protein phosphatase 2A interacts with the Src kinase substrate p130(CAS).Semantic proximity Read ↗

Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src.Semantic proximity Read ↗

Activation of p56lck through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylation.Semantic proximity Read ↗

Suppression of c-Src activity by C-terminal Src kinase involves the c-Src SH2 and SH3 domains: analysis with Saccharomyces cerevisiae.Semantic proximity Read ↗

The SH2 domain is required for stable phosphorylation of p56lck at tyrosine 505, the negative regulatory site.Semantic proximity Read ↗

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