Myristylation is required for Tyr-527 dephosphorylation and activation of pp60c-src in mitosis.

doi:10.1128/mcb.13.3.1464-1470.1993

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Article

Myristylation is required for Tyr-527 dephosphorylation and activation of pp60c-src in mitosis.

Molecular and cellular biology - 1 Mar 1993

Bagrodia S, Taylor S J, Shalloway D

Abstract excerpt

The chicken proto-oncoprotein c-Src is phosphorylated by p34cdc2 during mitosis concomitant with increased c-Src tyrosine kinase activity. On the basis of indirect evidence, we previously suggested that this is caused by partial dephosphorylation at Tyr-527, the phosphorylation of which suppresse...

Topics

Animals
CDC2 Protein Kinase
Chickens
Enzyme Activation
Mitosis
Mutation
Myristic Acid
Myristic Acids
Protein Processing, Post-Translational
Protein Tyrosine Phosphatases
Protein-Tyrosine Kinases
Proto-Oncogene Proteins pp60(c-src)
Tyrosine
Vanadates

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