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Article

DNA-sequence specificity of mutations at the human thymidine kinase locus.

Mutation research - 1 Oct 1993

Grosovsky A J, Walter B N, Giver C R

Abstract excerpt

We have established a system for the study of DNA-sequence specificity at a functionally heterozygous thymidine kinase (tk) locus in a human lymphoblastoid cell line (TK6). Characterization of the parental locus demonstrated that the 2 tk alleles were fortuitously distinguished by differential gene expression. One round of PCR amplification yielded a specific tk cDNA product only for the functional parental...

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Identifiers

PMID: 7690892
DOI: 10.1016/0027-5107(93)90074-p

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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