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Article

Single and coincident intragenic mutations attributable to gene conversion in a human cell line.

Genetics - 1 Aug 1997

Giver C R, Grosovsky A J

Abstract excerpt

Two polymorphic sites are located within the heterozygous TK1 locus in the human lymphoblastoid cell line TK6: an inactivating frameshift in exon 4 of the nonfunctional allele and a phenotypically silent frameshift in exon 7 of the functional allele. Through the use of these intragenic polymorphisms and microsatellite markers that flank TK1, we demonstrate that partial gene conversion accounts for 3/75 (0.04)...

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Identifiers

PMID: 9258685
DOI: 10.1093/genetics/146.4.1429
PMCID: PMC1208086

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Source receipt: pubmed, retrieved 7 Sept 2026.

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