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Article

The conserved terminal guanosine of a group I intron can help prevent reopening of the ligated exons.

Journal of molecular biology - 20 Jul 1993

Suh E, Waring R B

Abstract excerpt

The highly conserved terminal guanosine of the Tetrahymena group I intron was mutated to an adenosine. The intron still excised itself but more slowly than the wild-type. At very low concentrations of GTP only ligated exons were produced, but at high concentrations of GTP unligated exons accumulated and the 3' exon acquired a GTP at its 5' end. A series of experiments suggested that GTP was primarily reopening...

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Source

Identifiers

PMID: 7688426
DOI: 10.1006/jmbi.1993.1397

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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The conserved terminal guanosine of a group I intron can help prevent reopening of the ligated exons.PMID 7688426Read ↗

Requirements of a group I intron for reactions at the 3' splice site.Semantic proximity Read ↗

A 3' splice site-binding sequence in the catalytic core of a group I intron.Semantic proximity Read ↗

Two universally conserved adenosines of the group I intron that are important for self-splicing but not for core catalytic activity.Semantic proximity Read ↗

Alternative secondary structures in the 5' exon affect both forward and reverse self-splicing of the Tetrahymena intervening sequence RNA.Semantic proximity Read ↗

Increased efficiency of evolved group I intron spliceozymes by decreased side product formation.Semantic proximity Read ↗

Intracellular folding of the Tetrahymena group I intron depends on exon sequence and promoter choice.Semantic proximity Read ↗

The Tetrahymena ribozyme acts like an RNA restriction endonuclease.Semantic proximity Read ↗

A programmed site-specific DNA rearrangement in Tetrahymena thermophila requires flanking polypurine tracts.Semantic proximity Read ↗

Base pairing between the 3' exon and an internal guide sequence increases 3' splice site specificity in the Tetrahymena self-splicing rRNA intron.Semantic proximity Read ↗

Activation of the catalytic core of a group I intron by a remote 3' splice junction.Semantic proximity Read ↗

Sequence specificity of in vivo reverse splicing of the Tetrahymena group I intron.Semantic proximity Read ↗

An RNA internal loop acts as a hinge to facilitate ribozyme folding and catalysis.Semantic proximity Read ↗

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