The Tetrahymena ribozyme acts like an RNA restriction endonuclease.

doi:10.1038/324429a0

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Article

The Tetrahymena ribozyme acts like an RNA restriction endonuclease.

Nature - 1 Jan 2000

Zaug A J, Been M D, Cech T R

Abstract excerpt

A shortened form of the Tetrahymena self-splicing ribosomal RNA intervening sequence acts as an endoribonuclease, catalysing the cleavage of large RNA molecules by a mechanism involving guanosine transfer. The sequence specificity approaches that of the DNA restriction endonucleases. Site-specifi...

Topics

Animals
Base Sequence
Binding Sites
Kinetics
Mutation
RNA Splicing
RNA, Catalytic
RNA, Ribosomal
Substrate Specificity
Tetrahymena

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