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Article

Intracellular folding of the Tetrahymena group I intron depends on exon sequence and promoter choice.

RNA (New York, N.Y.) - 1 Oct 2004

Koduvayur Sujatha P, Woodson Sarah A

Abstract excerpt

The Tetrahymena group I intron splices 20 to 50 times faster in Tetrahymena than in vitro, implying that the intron rapidly adopts its active conformation in the cell. The importance of cotranscriptional folding and the contribution of the rRNA exons to the stability of the active pre-RNA structure were investigated by comparing the activity of minimal pre-RNAs expressed in Escherichia coli. Pre-RNAs containing...

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Identifiers

PMID: 15337845
DOI: 10.1261/rna.7880404
PMCID: PMC1370639

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