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Article

A programmed site-specific DNA rearrangement in Tetrahymena thermophila requires flanking polypurine tracts.

Cell - 29 Jun 1990

Godiska R, Yao M C

Abstract excerpt

During macronuclear development in ciliates, precise deletion events eliminate thousands of specific DNA segments. Each segment is bounded by a unique pair of short direct repeats, but no other common feature has been reported. To determine the critical cis-acting sequences, we developed an in vivo system for analyzing this process in Tetrahymena. We show that sequences essential for recognition and excision of...

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PMID: 2364428
DOI: 10.1016/0092-8674(90)90688-b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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