A programmed site-specific DNA rearrangement in Tetrahymena thermophila requires flanking polypurine tracts.

doi:10.1016/0092-8674(90)90688-b

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Article

A programmed site-specific DNA rearrangement in Tetrahymena thermophila requires flanking polypurine tracts.

Cell - 29 Jun 1990

Godiska R, Yao M C

Abstract excerpt

During macronuclear development in ciliates, precise deletion events eliminate thousands of specific DNA segments. Each segment is bounded by a unique pair of short direct repeats, but no other common feature has been reported. To determine the critical cis-acting sequences, we developed an in vi...

Topics

Animals
Base Sequence
Cell Line
Chromosome Deletion
Cloning, Molecular
DNA
Gene Rearrangement
Genetic Vectors
Molecular Sequence Data
Mutation
Oligonucleotide Probes
Plasmids
Repetitive Sequences, Nucleic Acid
Tetrahymena

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