Article
Importance of a conserved TCR J alpha-encoded tyrosine for T cell recognition of an HLA B27/peptide complex.
European journal of immunology - 1 Sept 1998
Bowness P, Allen R L, Barclay D N, Jones E Y, McMichael A J
Abstract excerpt
Human HLA B27-restricted cytotoxic T lymphocytes (CTL) specific for the influenza A epitope NP383-391 use similar TCR alpha and beta chains, with two closely related J alpha segments used by six of nine CTL clones from three unrelated donors (Bowness et al., Eur J. Immunol. 1993. 23: 1417-1421)....
Topics
- Amino Acid Sequence
- Animals
- Antigen Presentation
- Antigens, Viral
- Complementarity Determining Regions
- HLA-B27 Antigen
- Humans
- Immunoglobulin alpha-Chains
- Influenza A virus
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Rats
- Receptors, Antigen, T-Cell, alpha-beta