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Article

Importance of a conserved TCR J alpha-encoded tyrosine for T cell recognition of an HLA B27/peptide complex.

European journal of immunology - 1 Sept 1998

Bowness P, Allen R L, Barclay D N, Jones E Y, McMichael A J

Abstract excerpt

Human HLA B27-restricted cytotoxic T lymphocytes (CTL) specific for the influenza A epitope NP383-391 use similar TCR alpha and beta chains, with two closely related J alpha segments used by six of nine CTL clones from three unrelated donors (Bowness et al., Eur J. Immunol. 1993. 23: 1417-1421). The role of TCR complementarity-determining region (CDR)3alpha residues 93 and 100-102 was examined by site-directed...

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Source

Identifiers

PMID: 9754558
DOI: 10.1002/(SICI)1521-4141(199809)28:09<2704::AID-IMMU2704>3.0.CO;2-B

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APC

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