Article
Changes in the repertoire of peptides bound to HLA-B27 subtypes and to site-specific mutants inside and outside pocket B.
The Journal of experimental medicine - 1 Mar 1993
Rojo S, García F, Villadangos J A, López de Castro J A
Abstract excerpt
HLA-B27 subtypes share many structural features, including their pocket B, which interacts with a conserved Arg residue at the second position of B*2705-bound peptides. Subtypes differ among each other at other locations in the peptide binding site. In this study, metabolic labeling and radiochem...
Topics
- Amino Acid Sequence
- Amino Acids
- Arginine
- Cell Line
- Genetic Variation
- HLA-B27 Antigen
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Peptides
- Precipitin Tests
- Protein Binding
- Radiochemistry
- T-Lymphocytes, Cytotoxic
- Transfection