Article
Significance of the six peptide-binding pockets of HLA-A2.1 in influenza A matrix peptide-specific cytotoxic T-lymphocyte reactivity.
Human immunology - 1 Oct 1994
Matsui M, Moots R J, McMichael A J, Frelinger J A
Abstract excerpt
To evaluate the roles of the six peptide-binding pockets of HLA-A2.1 in FMP-specific CTL recognition, we have constructed an extensive library of HMy2.C1R cell lines expressing mutant HLA-A2.1 molecules with different amino acid substitutions in each of the six pockets. These cell lines were tested for their ability to present synthetic FMP 58-66 to FMP-specific, HLA-A2.1-restricted human CTL lines. Six of 12...
Topics
- Antigen Presentation
- Cell Line
- HLA-A2 Antigen
- Humans
- Influenza A virus
- Mutation
- T-Lymphocytes, Cytotoxic
- Viral Matrix Proteins