Article
Topoisomerase II activity in a DNA double-strand break repair deficient Chinese hamster ovary cell line.
Mutation research - 1 Mar 1991
Warters R L, Lyons B W, Li T M, Chen D J
Abstract excerpt
Topoisomerase II activity was measured in wild-type, Chinese hamster ovary K1 cells, and in the DNA double-strand break repair deficient xrs-6 cell line. Total topoisomerase II activity in a high salt, nuclear extract was found to be the same in both cell lines, as measured by decatenation of kin...
Topics
- Amsacrine
- Animals
- Cell Line
- Cell Survival
- Cricetinae
- DNA Damage
- DNA Repair
- DNA Topoisomerases, Type II
- DNA, Single-Stranded
- Dose-Response Relationship, Drug
- Female
- In Vitro Techniques
- Mutation