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New insights into the function of the Wilms tumor suppressor geneWT1in podocytes

3 Apr 2008

Abstract excerpt

The Wilms tumor suppressor gene WT1 is essential for early urogenital development: homozygous mutations in WT1 result in embryonic lethality due to a failure in the development of kidneys and gonads. In the adult kidney, WT1 expression is limited to the glomerular podocytes. Several human nephrotic diseases arise from mutations of the WT1 gene, including mutations that affect its zinc-fingers and alternative...

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PMID: 18385267
DOI: 10.1152/ajprenal.00597.2007

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