Selection for spontaneous null mutations in a chromosomally-integrated HSV-1 thymidine kinase gene yields deletions and a mutation caused by intragenic illegitimate recombination.

doi:10.1016/0027-5107(93)90012-5

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Article

Selection for spontaneous null mutations in a chromosomally-integrated HSV-1 thymidine kinase gene yields deletions and a mutation caused by intragenic illegitimate recombination.

Mutation research - 1 Jun 1993

Brisebois J J, DuBow M S

Abstract excerpt

Spontaneous null mutations represent low frequency events that irreversibly and completely inactivate a gene, and can often consist of major gene alterations. To study the molecular mechanisms leading to recessive spontaneous null mutations in the human genome, we designed and tested a selection...

Topics

Base Sequence
Blotting, Western
Cell Line
Gene Conversion
Gene Deletion
Genome, Human
Humans
Molecular Sequence Data
Mutation
Recombination, Genetic
Simplexvirus
Thymidine Kinase

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