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Article

Spontaneous mutation rates in mammalian cells: effect of differential growth rates and phenotypic lag.

Genetics - 1 Oct 1990

Rudd C J, Daston D S, Caspary W J

Abstract excerpt

We calculated a spontaneous rate of 26-37 x 10(-6) mutations per cell division for L5178Y MOLY (mouse lymphoma) cells at the thymidine kinase locus (tk+/(-)----tk-/-) using a procedure that isolated and segregated cells during expression. This rate was 50 times higher than when cells expressed the mutant phenotype in suspension. The higher mutation rates obtained with the in situ procedure suggest that many of...

Topics

Animals
Cell Division
Drug Resistance
Kinetics
Mice
Mutation
Phenotype
Trifluridine
Tumor Cells, Cultured

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2123164
DOI: 10.1093/genetics/126.2.435
PMCID: PMC1204197

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2123164-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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