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Article

Quantitative analysis of clinically relevant mutations occurring in lymphoid cells harboring gamma-retrovirus-encoded hsvtk suicide genes.

Gene therapy - 1 Nov 2008

Wang X, Olszewska M, Capacio V, Stefanski J, Przybylowski M, Samakoglu S, Chang A H, Sadelain M, Rivière I

Abstract excerpt

The in vivo regulation of T lymphocyte activity by the activation of a suicide mechanism is an essential paradigm for the safety of adoptive cell therapies. In light of reports showing that gamma-retroviral vector-encoded herpes simplex virus thymidine kinase (hsvtk) undergoes recombination, we undertook a thorough investigation of the genomic stability of SFG-based vectors using two variants of the wild-type...

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Identifiers

PMID: 18563185
DOI: 10.1038/gt.2008.103
PMCID: PMC4528371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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