Article
Ex vivo analysis of human T lymphotropic virus type 1-specific CD4+ cells by use of a major histocompatibility complex class II tetramer composed of a neurological disease-susceptibility allele and its immunodominant peptide.
The Journal of infectious diseases - 15 Dec 2007
Nose Hirohisa, Kubota Ryuji, Seth Nilufer P, Goon Peter K, Tanaka Yuetsu, Izumo Shuji, Usuku Koichiro, Ohara Yoshiro, Wucherpfennig Kai W, Bangham Charles R M, Osame Mitsuhiro, Saito Mineki
Abstract excerpt
HLA-DRB1*0101 is associated with susceptibility to human T lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Here, we used a synthetic tetramer of DRB1*0101 and its epitope peptide to analyze HTLV-1-specific CD4(+) T cells ex vivo. The frequency of tetramer(+)CD4(+) T cells was significantly greater in patients with HAM/TSP than in healthy HTLV-1 carriers (HCs) at a...
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