Article
HLA Class II Genotype Does Not Affect the Myelin Responsiveness of Multiple Sclerosis Patients.
Cells - 17 Dec 2020
Derdelinckx Judith, Nkansah Irene, Ooms Naomi, Van Bruggen Laura, Emonds Marie-Paule, Daniëls Liesbeth, Reynders Tatjana, Willekens Barbara, Cras Patrick, Berneman Zwi N, Cools Nathalie
Abstract excerpt
BACKGROUND: When aiming to restore myelin tolerance using antigen-specific treatment approaches in MS, the wide variety of myelin-derived antigens towards which immune responses are targeted in multiple sclerosis (MS) patients needs to be taken into account. Uncertainty remains as to whether the myelin reactivity pattern of a specific MS patient can be predicted based upon the human leukocyte antigen (HLA) class...
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