Article
Preferential peptide specificity and HLA restriction of myelin basic protein-specific T cell clones derived from MS patients.
Cellular immunology - 1 Aug 1990
Zhang J W, Chou C H, Hashim G, Medaer R, Raus J C
Abstract excerpt
A panel of 17 myelin basic protein (MBP)-specific T lymphocyte clones were generated from four multiple sclerosis (MS) patients. All T cell clones expressed CD4 phenotype and 14 clones exhibited substantial cytotoxic activity on MBP-coated target cells. T cell recognition sites of the clones on human MBP were identified by using MBP fragments and synthetic peptides. Despite the fact that at least three epitopes...
Topics
- Amino Acid Sequence
- CD4-Positive T-Lymphocytes
- Clone Cells
- Cytotoxicity, Immunologic
- Epitopes
- HLA-D Antigens
- Humans
- Molecular Sequence Data
- Multiple Sclerosis
- Myelin Basic Protein
- Peptide Fragments