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Article

Human T-cell response to myelin basic protein peptide (83-99): extensive heterogeneity in antigen recognition, function, and phenotype.

Neurology - 1 Oct 1997

Hemmer B, Vergelli M, Tranquill L, Conlon P, Ling N, McFarland H F, Martin R

Abstract excerpt

Multiple sclerosis (MS) is considered a T cell-mediated autoimmune disease, and myelin proteins are the most likely candidate autoantigens. Based on experiments performed in experimental allergic encephalomyelitis (EAE), innovative immunotherapies have been developed that target either the specif...

Topics

Antigens
Antigens, Surface
Cell Division
Clone Cells
Cytokines
Dose-Response Relationship, Drug
Humans
Myelin Basic Protein
Peptide Fragments
Phenotype
Receptors, Antigen, T-Cell
T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9339699
DOI: 10.1212/wnl.49.4.1116

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9339699-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Human T-cell response to myelin basic protein peptide (83-99): extensive heterogeneity in antigen recognition, function, and phenotype.PMID 9339699Read ↗

Cytokine phenotype of human autoreactive T cell clones specific for the immunodominant myelin basic protein peptide (83-99).Semantic proximity Read ↗

Preferential peptide specificity and HLA restriction of myelin basic protein-specific T cell clones derived from MS patients.Semantic proximity Read ↗

The T-cell response to myelin basic protein in familial multiple sclerosis: diversity of fine specificity, restricting elements, and T-cell receptor usage.Semantic proximity Read ↗

Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients.Semantic proximity Read ↗

Diversity of the anti-T-cell receptor immune response and its implications for T-cell vaccination therapy of multiple sclerosis.Semantic proximity Read ↗

Activation of a myelin basic protein-specific human T cell clone by antigen-presenting cells from rhesus monkeys.Semantic proximity Read ↗

Cutting edge: myelin basic protein-specific cytotoxic T cell tolerance is maintained in vivo by a single dominant epitope in H-2k mice.Semantic proximity Read ↗

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Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones.Semantic proximity Read ↗

T helper 1 (Th1) functional phenotype of human myelin basic protein-specific T lymphocytes.Semantic proximity Read ↗

A double mutation of MBP(83-99) peptide induces IL-4 responses and antagonizes IFN-gamma responses.Semantic proximity Read ↗

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