Article
A human leucocyte antigen-DR1 transgene confers susceptibility to experimental allergic encephalomyelitis elicited by an epitope of myelin basic protein.
Scandinavian journal of immunology - 1 Aug 2003
Sireci G, Dieli F, Caccamo N, Barera A, Carta P, Di Sano C, Meraviglia S, Bonanno C T, Salerno A
Abstract excerpt
Much evidence now indicates that human leucocyte antigen (HLA) class I and class II transgenic (Tg) mice can be of value in analysing HLA-restricted presentation of T-cell epitopes relevant to experimental models of autoimmune diseases. One area where this has been applied is the characterization of myelin epitopes presented by HLA class II molecules in experimental model of multiple sclerosis (experimental...
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