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Article

Zidovudine-resistant human immunodeficiency virus type 1 genomes detected in plasma distinct from viral genomes in peripheral blood mononuclear cells.

The Journal of infectious diseases - 1 Feb 1993

Smith M S, Koerber K L, Pagano J S

Abstract excerpt

The emergence of zidovudine (3'-azido-2',3'-deoxythymidine)-resistant strains of human immunodeficiency virus type 1 (HIV-1) from AIDS patients treated with zidovudine has been linked to six amino acid substitutions localized within the viral polymerase gene. Here, in 2 patients, three resistance...

Topics

Acquired Immunodeficiency Syndrome
DNA, Viral
Dose-Response Relationship, Drug
Drug Resistance, Microbial
Genotype
HIV Reverse Transcriptase
HIV-1
Humans
Leukocytes, Mononuclear
Mutation
Plasma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

RNA-Directed DNA Polymerase

Zidovudine

Source

Identifiers

PMID: 7678429
DOI: 10.1093/infdis/167.2.445

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7678429-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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