Article
Zidovudine resistance predicted by direct detection of mutations in DNA from HIV-infected lymphocytes.
AIDS (London, England) - 1 Feb 1991
Larder B A, Kellam P, Kemp S D
Abstract excerpt
Zidovudine-resistant strains of HIV have recently been isolated from individuals during prolonged treatment. Analysis of the HIV reverse transcriptase (RT) gene from clinical isolates revealed that resistance was due to multiple nucleotide changes conferring specific amino acid substitutions in t...
Topics
- AIDS-Related Complex
- Acquired Immunodeficiency Syndrome
- Base Sequence
- Cell Line
- Cloning, Molecular
- DNA, Viral
- Drug Resistance, Microbial
- HIV
- HeLa Cells
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- RNA-Directed DNA Polymerase
- T-Lymphocytes
- Zidovudine