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Article

Zidovudine resistance predicted by direct detection of mutations in DNA from HIV-infected lymphocytes.

AIDS (London, England) - 1 Feb 1991

Larder B A, Kellam P, Kemp S D

Abstract excerpt

Zidovudine-resistant strains of HIV have recently been isolated from individuals during prolonged treatment. Analysis of the HIV reverse transcriptase (RT) gene from clinical isolates revealed that resistance was due to multiple nucleotide changes conferring specific amino acid substitutions in this enzyme. In order to correlate the degree of resistance with these amino acid changes, we constructed a series of...

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Identifiers

PMID: 1709563
DOI: 10.1097/00002030-199102000-00002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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