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Article

Quantitation of zidovudine-resistant human immunodeficiency virus type 1 in the blood of treated and untreated patients.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1993

Mohri H, Singh M K, Ching W T, Ho D D

Abstract excerpt

A nonselective ex vivo assay was used to directly detect and quantify zidovudine (AZT)-resistant human immunodeficiency virus type 1 (HIV-1) in the blood of treated and untreated patients. In contrast to previous reports, drug-resistant virus was detected in peripheral blood mononuclear cells of a few of the patients who had never received AZT. The AZT resistance of HIV-1 isolates from one untreated individual...

Topics

AIDS-Related Complex
Acquired Immunodeficiency Syndrome
Amino Acid Sequence
Drug Resistance, Microbial
Female
HIV Reverse Transcriptase
HIV Seropositivity
HIV-1
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

RNA-Directed DNA Polymerase

Zidovudine

Source

Open in PubMed Open full text

Identifiers

PMID: 7678340
DOI: 10.1073/pnas.90.1.25
PMCID: PMC45592

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7678340-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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