Article
Both human immunodeficiency virus cellular DNA sequencing and plasma RNA sequencing are useful for detection of drug resistance mutations in blood samples from antiretroviral-drug-naive patients.
Journal of clinical microbiology - 1 Jun 2007
Parisi Saverio G, Boldrin Caterina, Cruciani Mario, Nicolini Giangiacomo, Cerbaro Isabella, Manfrin Vinicio, Dal Bello Federico, Franchin Elisa, Franzetti Marzia, Rossi Maria C, Cattelan Anna M, Romano Laura, Zazzi Maurizio, Andreoni Massimo, Palù Giorgio
Abstract excerpt
Genotypic antiretroviral testing is recommended for newly infected drug-naive subjects, and the material of choice is plasma RNA. Since drug resistance mutations (DRMs) may persist longer in cellular DNA than in plasma RNA, we investigated whether the use of peripheral blood mononuclear cell (PBM...
Topics
- Adult
- Anti-HIV Agents
- DNA, Viral
- Drug Resistance, Viral
- Female
- HIV Infections
- HIV-1
- Humans
- Leukocytes, Mononuclear
- Male