Heterosexual transmission of human immunodeficiency virus type 1 variants associated with zidovudine resistance.

doi:10.1093/infdis/169.2.411

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Article

Heterosexual transmission of human immunodeficiency virus type 1 variants associated with zidovudine resistance.

The Journal of infectious diseases - 1 Feb 1994

Conlon C P, Klenerman P, Edwards A, Larder B A, Phillips R E

Abstract excerpt

During zidovudine therapy, human immunodeficiency virus type 1 (HIV-1) acquires a distinctive set of mutations that diminish the sensitivity of the virus to this drug in vitro. An AIDS patient is described who, while being treated with zidovudine, transmitted HIV-1 bearing a drug resistance mutation to a young woman who had never received zidovudine treatment. DNA sequencing of HIV-1 proviruses confirmed that...

Topics

Adult
Base Sequence
DNA Primers
Drug Resistance, Microbial
Female
Genetic Variation
HIV Infections
HIV Reverse Transcriptase
HIV-1
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Point Mutation

Polymerase Chain Reaction

RNA-Directed DNA Polymerase

Sexual Behavior

Time Factors

Zidovudine

Source

Open in PubMed

Identifiers

PMID: 7508970
DOI: 10.1093/infdis/169.2.411

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7508970-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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