Article
Emergence of protease inhibitor resistance-associated mutations in plasma HIV-1 precedes that in proviruses of peripheral blood mononuclear cells by more than a year.
Journal of acquired immune deficiency syndromes (1999) - 1 Sept 2003
Bi Xiuqiong, Gatanaga Hiroyuki, Ida Setsuko, Tsuchiya Kiyoto, Matsuoka-Aizawa Saori, Kimura Satoshi, Oka Shinichi
Abstract excerpt
HIV-1 genotype assay using plasma viruses has been widely applied for detection of resistant viruses in infected individuals, whereas there are only a few reports about proviral genotype in peripheral blood mononuclear cells (PBMCs). To determine which sample, plasma or PBMC, should be used for early detection of drug-resistant viruses during antiretroviral treatment, we analyzed 275 plasma-derived and 211...
Topics
- Antiretroviral Therapy, Highly Active
- DNA, Viral
- Drug Resistance, Viral
- HIV Infections
- HIV Protease
- HIV Protease Inhibitors
- HIV-1
- Humans
- Leukocytes, Mononuclear
- Microbial Sensitivity Tests