Article
Long-term persistence of zidovudine resistance mutations in plasma isolates of human immunodeficiency virus type 1 of dideoxyinosine-treated patients removed from zidovudine therapy.
The Journal of infectious diseases - 1 Jan 1994
Smith M S, Koerber K L, Pagano J S
Abstract excerpt
Zidovudine (3'-azido-2',3'-dideoxythymidine)-resistant isolates of human immunodeficiency virus type 1 (HIV-1) were previously demonstrated in zidovudine-treated AIDS patients. The genetic linkage of multiple mutations characteristic of zidovudine resistance as well as dideoxyinosine resistance were demonstrated by examining clones of viral reverse transcriptase after polymerase chain reaction amplification of...
Topics
- Acquired Immunodeficiency Syndrome
- Cloning, Molecular
- DNA, Viral
- Didanosine
- Dose-Response Relationship, Drug
- Drug Resistance, Microbial
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Microbial Sensitivity Tests