Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Long-term persistence of AZT-resistance mutations in the plasma HIV-1 of patients removed from AZT therapy.

Leukemia - 1 Apr 1994

Smith M S, Koerber K L, Pagano J S

Abstract excerpt

Zidovudine (3'-azido-2',3'-dideoxythymidine) resistant isolates of human immunodeficiency virus type I (HIV-1) were previously demonstrated in zidovudine-treated AIDS patients. The genetic linkage of multiple mutations characteristic of zidovudine-resistance as well as dideoxyinosine-resistance were demonstrated by examining clones of viral reverse transcriptase after polymerase chain reaction (PCR) amplification...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acquired Immunodeficiency Syndrome
Share to Drug Resistance
Share to HIV-1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Time Factors

Share to Zidovudine

Source

Identifiers

PMID: 8152287

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Long-term persistence of AZT-resistance mutations in the plasma HIV-1 of patients removed from AZT therapy.PMID 8152287Read ↗

Long-term persistence of zidovudine resistance mutations in plasma isolates of human immunodeficiency virus type 1 of dideoxyinosine-treated patients removed from zidovudine therapy.Semantic proximity Read ↗

Persistence of azidothymidine-resistant human immunodeficiency virus type 1 RNA genotypes in posttreatment sera.Semantic proximity Read ↗

Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase.Semantic proximity Read ↗

Quantitation of zidovudine-resistant human immunodeficiency virus type 1 in the blood of treated and untreated patients.Semantic proximity Read ↗

Emergence of dual resistance to zidovudine and lamivudine in HIV-1-infected patients treated with zidovudine plus lamivudine as initial therapy.Semantic proximity Read ↗

Dynamic changes in HIV-1 quasispecies from azidothymidine (AZT)-treated patients.Semantic proximity Read ↗

Zidovudine-resistant human immunodeficiency virus type 1 genomes detected in plasma distinct from viral genomes in peripheral blood mononuclear cells.Semantic proximity Read ↗

In vivo comparison of zidovudine resistance mutations in blood and CSF of HIV-1-infected patients.Semantic proximity Read ↗

Potential Mechanism for Sustained Antiretroviral Efficacy of AZT-3TC Combination TherapySemantic proximity Read ↗

Reverse transcriptase mutations in sequential HIV-1 isolates in a patient with AIDS.Semantic proximity Read ↗

Intermittent selection pressure with zidovudine plus zalcitabine treatment reduces the emergence in vivo of zidovudine resistance HIV mutations.Semantic proximity Read ↗

Natural resistance of human immunodeficiency virus type 2 to zidovudine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.