Article
Zidovudine resistance mutations and human immunodeficiency virus type 1 DNA burden: longitudinal evaluation of six patients under treatment.
Infection - 1 Jan 2000
Zazzi M, Catucci M, De Milito A, Romano L, Venturi G, Almi P, Gonnelli A, Rubino M, Valensin P E
Abstract excerpt
Zidovudine (ZDV) is by far the most widely used drug to counteract human immunodeficiency virus type 1 (HIV-1) infection, both in monotherapy and in combination therapy regimens. However, the majority of patients under prolonged ZDV therapy have been shown to harbour HIV-1 mutant genomes displayi...
Topics
- Adult
- Anti-HIV Agents
- CD4 Lymphocyte Count
- DNA, Viral
- Drug Monitoring
- Drug Resistance
- Genes, pol
- Genotype
- HIV Infections
- HIV-1
- Humans
- Longitudinal Studies