Article
A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids.
The Journal of biological chemistry - 3 Apr 1998
Bokoch G M, Reilly A M, Daniels R H, King C C, Olivera A, Spiegel S, Knaus U G
Abstract excerpt
p21-activated kinases (PAKs) are serine/threonine kinases that have been identified as targets for the small GTPases Rac and Cdc42. PAKs have been implicated in cytoskeletal regulation, stimulation of mitogen-activated protein kinase cascades, and in control of the phagocyte NADPH oxidase. Membra...
Topics
- Animals
- COS Cells
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Enzyme Activation
- GTP Phosphohydrolases
- Mutation
- Protein Serine-Threonine Kinases
- Sphingomyelin Phosphodiesterase
- Sphingosine
- p21-Activated Kinases