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Article

Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction.

Molecular and cellular biology - 1 Dec 1993

Cai H, Erhardt P, Troppmair J, Diaz-Meco M T, Sithanandam G, Rapp U R, Moscat J, Cooper G M

Abstract excerpt

We have investigated the relationship between hydrolysis of phosphatidylcholine (PC) and activation of the Raf-1 protein kinase in Ras-mediated transduction of mitogenic signals. As previously reported, cotransfection of a PC-specific phospholipase C (PC-PLC) expression plasmid bypassed the block...

Topics

3T3 Cells
Animals
Cell Division
Enzyme Activation
Genes, ras
Hydrolysis
Mice
Mutation
Phosphatidylcholines
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-raf
Signal Transduction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transfection

Type C Phospholipases

Source

Open in PubMed Open full text

Identifiers

PMID: 8246981
DOI: 10.1128/mcb.13.12.7645-7651.1993
PMCID: PMC364836

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8246981-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction.PMID 8246981Read ↗

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