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Article

Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction.

Molecular and cellular biology - 1 Dec 1993

Cai H, Erhardt P, Troppmair J, Diaz-Meco M T, Sithanandam G, Rapp U R, Moscat J, Cooper G M

Abstract excerpt

We have investigated the relationship between hydrolysis of phosphatidylcholine (PC) and activation of the Raf-1 protein kinase in Ras-mediated transduction of mitogenic signals. As previously reported, cotransfection of a PC-specific phospholipase C (PC-PLC) expression plasmid bypassed the block to cell proliferation resulting from expression of the dominant inhibitory mutant Ras N-17. In contrast, PC-PLC failed...

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Identifiers

PMID: 8246981
DOI: 10.1128/mcb.13.12.7645-7651.1993
PMCID: PMC364836

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction.PMID 8246981Read ↗

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