Article
Phosphatidylinositol 3-kinase-gamma activates Bruton's tyrosine kinase in concert with Src family kinases.
Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 1997
Li Z, Wahl M I, Eguinoa A, Stephens L R, Hawkins P T, Witte O N
Abstract excerpt
Bruton's tyrosine kinase (Btk) is essential for normal B lymphocyte development and function. The activity of Btk is partially regulated by transphosphorylation within its kinase domain by Src family kinases at residue Tyr-551 and subsequent autophosphorylation at Tyr-223. Activation correlates w...
Topics
- Agammaglobulinaemia Tyrosine Kinase
- Alleles
- Animals
- B-Lymphocytes
- Binding Sites
- Blood Proteins
- Cell Line
- Enzyme Activation
- Fibroblasts
- Gene Expression
- Models, Biological
- Mutation
- Peptide Mapping
- Phosphatidylinositol 3-Kinases
- Phosphoproteins
- Phosphorylation
- Protein Conformation
- Protein-Tyrosine Kinases