Article
Dynamic analysis of heterogeneous hepatitis C virus populations by direct solid-phase sequencing.
Journal of clinical microbiology - 1 Jul 1995
Odeberg J, Yun Z, Sönnerborg A, Uhlén M, Lundeberg J
Abstract excerpt
In the present study, we used a semiautomated solid-phase direct sequencing method to analyze sequence diversity and variation of the hypervariable E2/NS1 region in the hepatitis C virus (HCV) genome in isolates from patients seropositive for HCV. A total of 24 isolates of various origins were se...
Topics
- Amino Acid Sequence
- Base Sequence
- Cloning, Molecular
- DNA Primers
- DNA, Viral
- Genetic Variation
- Hepacivirus
- Hepatitis C
- Humans
- Molecular Sequence Data
- Phylogeny
- Polymerase Chain Reaction
