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Article

Dynamic analysis of heterogeneous hepatitis C virus populations by direct solid-phase sequencing.

Journal of clinical microbiology - 1 Jul 1995

Odeberg J, Yun Z, Sönnerborg A, Uhlén M, Lundeberg J

Abstract excerpt

In the present study, we used a semiautomated solid-phase direct sequencing method to analyze sequence diversity and variation of the hypervariable E2/NS1 region in the hepatitis C virus (HCV) genome in isolates from patients seropositive for HCV. A total of 24 isolates of various origins were sequenced. Six of the patients, not subject to any antiviral therapy, were monitored longitudinally, and rapid sequence...

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Identifiers

PMID: 7665662
DOI: 10.1128/jcm.33.7.1870-1874.1995
PMCID: PMC228288

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