Article
Nucleotide sequence and mutation rate of the H strain of hepatitis C virus.
Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1991
Ogata N, Alter H J, Miller R H, Purcell R H
Abstract excerpt
Patient H is an American patient who was infected with hepatitis C virus (HCV) in 1977. The patient became chronically infected and has remained so for the past 13 years. In this study, we compared the nucleotide and predicted amino acid sequences of the HCV genome obtained from plasma collected in 1977 with that collected in 1990. We find that the two HCV isolates differ at 123 of the 4923 (2.50%) nucleotides...
Topics
- Amino Acid Sequence
- Base Sequence
- Capsid
- Genes, Viral
- Hepacivirus
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- RNA, Viral
- Viral Core Proteins
- Viral Envelope Proteins