Dynamics of genome change in the E2/NS1 region of hepatitis C virus in vivo.

doi:10.1006/viro.1993.1641

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Article

Dynamics of genome change in the E2/NS1 region of hepatitis C virus in vivo.

Virology - 1 Dec 1993

Higashi Y, Kakumu S, Yoshioka K, Wakita T, Mizokami M, Ohba K, Ito Y, Ishikawa T, Takayanagi M, Nagai Y

Abstract excerpt

To substantiate and extend the quasispecies model of hepatitis C virus (HCV), we made a pairwise comparison in the nucleotide and deduced amino acid sequences for multiple recombinant clones of the E2/NS1 region, which derived from each blood sample taken from five patients of subtype II or subtype III infection at different stages. Sequence heterogeneity among the clones was generally high. The heterogeneity,...

Topics

Aged
Amino Acid Sequence
Chronic Disease
Female
Genes, Viral
Genetic Variation
Genome, Viral
Hepatitis C
Humans
Male
Middle Aged
Models, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Sequence Homology, Amino Acid

Species Specificity

Time Factors

Viral Nonstructural Proteins

Viral Proteins

Source

Open in PubMed

Identifiers

PMID: 8249288
DOI: 10.1006/viro.1993.1641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8249288-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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