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Article

Study of multiple genetic variations caused by persistent hepatitis C virus replication in long-term cell culture.

Archives of virology - 1 Feb 2020

Kato Nobuyuki, Ueda Youki, Sejima Hiroe, Gu Weilin, Satoh Shinya, Dansako Hiromichi, Ikeda Masanori, Shimotohno Kunitada

Abstract excerpt

The most characteristic feature of the hepatitis C virus (HCV) genome in patients with chronic hepatitis C is its remarkable variability and diversity. To better understand this feature, we performed genetic analysis of HCV replicons recovered from two human hepatoma HuH-7-derived cell lines after 1, 3, 5, 7, and 9 years in culture: The cell lines 50-1 and sO harbored HCV 1B-1 and O strain-derived HCV replicons...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 31832864
DOI: 10.1007/s00705-019-04461-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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