Article
HCV genome-wide genetic analyses in context of disease progression and hepatocellular carcinoma.
PloS one - 1 Jan 2014
Donlin Maureen J, Lomonosova Elena, Kiss Alexi, Cheng Xiaohong, Cao Feng, Curto Teresa M, Di Bisceglie Adrian, Tavis John E
Abstract excerpt
Hepatitis C virus (HCV) is a major cause of hepatitis and hepatocellular carcinoma (HCC) world-wide. Most HCV patients have relatively stable disease, but approximately 25% have progressive disease that often terminates in liver failure or HCC. HCV is highly variable genetically, with seven genotypes and multiple subtypes per genotype. This variation affects HCV's sensitivity to antiviral therapy and has been...
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