Article
Genetic characterization of hepatitis C virus in long-term RNA replication using Li23 cell culture systems.
PloS one - 1 Jan 2014
Kato Nobuyuki, Sejima Hiroe, Ueda Youki, Mori Kyoko, Satoh Shinya, Dansako Hiromichi, Ikeda Masanori
Abstract excerpt
BACKGROUND: The most distinguishing genetic feature of hepatitis C virus (HCV) is its remarkable diversity and variation. To understand this feature, we previously performed genetic analysis of HCV in the long-term culture of human hepatoma HuH-7-derived HCV RNA-replicating cell lines. On the other hand, we newly established HCV RNA-replicating cell lines using human hepatoma Li23 cells, which were distinct from...
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