Article
Characterization of hypervariable region in hepatitis C virus envelope protein during acute and chronic infection.
Archives of virology - 1 May 2005
Higashi K, Tsukiyama-Kohara K, Tanaka T, Tanaka E, Kiyosawa K, Kohara M
Abstract excerpt
Hepatitis C virus (HCV) causes persistent infection in most patients. To clarify the mechanisms underlying establishment of this persistent infection, nucleotide sequences of the E1/E2 region were characterized in 5 patients with acute and chronic HCV infection. We used direct DNA sequencing methods to identify the major sequence of HCV in each patient. Each HCV genome displayed a high frequency of nucleotide...
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