Article
Age and TP53 mutation frequency in childhood malignant gliomas: results in a multi-institutional cohort.
Cancer research - 15 Oct 2001
Pollack I F, Finkelstein S D, Burnham J, Holmes E J, Hamilton R L, Yates A J, Finlay J L, Sposto R
Abstract excerpt
Malignant astrocytoma is one of the most deadly primary central nervous system tumors. Although significant progress has been made in understanding the molecular pathways that lead to the development of these tumors in adults, comparatively little analysis has been done in childhood astrocytomas, which are less common and have a more favorable prognosis. Our previous studies of an institutional cohort of children...
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