Article
p53 mutations in malignant gliomas.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 1998
Li Y, Millikan R C, Carozza S, Newman B, Liu E, Davis R, Miike R, Wrensch M
Abstract excerpt
A population-based series of incident cases of malignant glioma were analyzed for mutations in the tumor suppressor gene p53. Exons 4-8 were screened using PCR-single-strand conformation analysis and confirmed through direct sequencing. Of 62 tumors analyzed, 12 (19%) contained mutations in p53:...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Black People
- Brain Neoplasms
- DNA, Neoplasm
- Female
- Genes, p53
- Glioma
- Humans
- Male
- Middle Aged
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- San Francisco
- White People