Article
Distance constraints and stereospecific alignment requirements characteristic of p53 DNA-binding consensus sequence homologies.
Oncogene - 17 Aug 1995
Cook J L, Ré R N, Giardina J F, Fontenot F E, Cheng D Y, Alam J
Abstract excerpt
We present evidence in favor of the position that some mutant p53 proteins retain the ability to trans-activate downstream genes through p53 DNA-binding consensus sequence (CS) homologies. We tested one cell line possessing high levels of mutant p53 and found that this mutant p53 is highly active in trans-activating one CS homology, moderately active in trans-activating a second sequence and inactive in...
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