Article
Distance constraints and stereospecific alignment requirements characteristic of p53 DNA-binding consensus sequence homologies.
Oncogene - 17 Aug 1995
Cook J L, Ré R N, Giardina J F, Fontenot F E, Cheng D Y, Alam J
Abstract excerpt
We present evidence in favor of the position that some mutant p53 proteins retain the ability to trans-activate downstream genes through p53 DNA-binding consensus sequence (CS) homologies. We tested one cell line possessing high levels of mutant p53 and found that this mutant p53 is highly active...
Topics
- Amino Acid Sequence
- Base Sequence
- Cell Line
- Consensus Sequence
- DNA Primers
- DNA-Binding Proteins
- HeLa Cells
- Humans
- Luciferases
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Sequence Homology, Amino Acid
- Sequence Homology, Nucleic Acid
- TATA Box
- Transcriptional Activation
- Transfection
- Tumor Cells, Cultured