Article
Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code.
Nucleic acids research - 1 Oct 2013
Ciribilli Yari, Monti Paola, Bisio Alessandra, Nguyen H Thien, Ethayathulla Abdul S, Ramos Ana, Foggetti Giorgia, Menichini Paola, Menendez Daniel, Resnick Michael A, Viadiu Hector, Fronza Gilberto, Inga Alberto
Abstract excerpt
Structural and biochemical studies have demonstrated that p73, p63 and p53 recognize DNA with identical amino acids and similar binding affinity. Here, measuring transactivation activity for a large number of response elements (REs) in yeast and human cell lines, we show that p53 family proteins also have overlapping transactivation profiles. We identified mutations at conserved amino acids of loops L1 and L3 in...
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