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Article

Mutant bZip-DNA complexes with four quasi-identical protein-DNA interfaces.

The EMBO journal - 1 Feb 1996

Suckow M, Lopata M, Seydel A, Kisters-Woike B, von Wilcken-Bergmann B, Müller-Hill B

Abstract excerpt

The complex between the yeast transcriptional activator GCN4 and the palindromic ATF/CREB site 5'- A4T3G2A1C0*G0'T1'C2'A3'T4'-3' shows dyad symmetry. The basic region of GCN4 contains a segment of 18 amino acids with a partially palindromic sequence: N-LKRARNTEA*ARRSRARKL-C. Symmetric residues are underlined. Apart from the ATF/CREB site, GCN4 also binds well to the symmetric variants with guanine in position 4...

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PMID: 8599943
PMCID: PMC449978

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