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Influence of amino acid numbers between two ligand cysteines of zinc finger proteins on affinity and specificity of DNA binding.

Biochemical and biophysical research communications - 23 Aug 2002

Nagaoka Makoto, Kondo Yumi, Uno Yumiko, Sugiura Yukio

Abstract excerpt

The C(2)H(2)-type zinc finger motif has the consensus sequence X(2)-Cys-X(2,4)-Cys-X(12)-His-X(3-5)-His and two or four amino acid residues between two ligand cysteines are well conserved. To evaluate this conservation, we prepared six mutant peptides derived from the three-zinc-finger domain of Sp1 whose C-terminal finger has two amino acid residues between the two invariant cysteines. Their circular dichroism...

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PMID: 12176016
DOI: 10.1016/s0006-291x(02)00898-7

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Source receipt: pubmed, retrieved 7 Sept 2026.

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